Objective:To observe the expression of cytokine receptor in neuron and astrocyte of the hippocampus of rats in depression. Methods:The depression model was produced by separation and un-predicted mild stressors. The behavior was measured by open -field test.The rats acceived electric convulsive therapy(ECT) or modified electric convulsive therapy (MECT)treatment. The expression of cytokine receptor in neuron and astrocyte of the hippocampus was observed by the immunofluorescence detection technique. Results:There were significant differences among the stress and ECT group

the stress and MECT group and the stress and shame-electroshock group in the two test. Conclusion:Both the ECT and the MECT treatment can promote the expression of cytokine receptor in neuron and astrocyte of the hippocampus of rats in depression. The cytokine(CK)may play an important role in the pathophysiological mechanism of depression. And the MECT treatment may be more effective than the ECT treatment.