Objective:To investigate the relationship between high density lipoprotein cholesterol(HDL-C)and coronary heart disease(CHD).Methods:A total of 427 CHD patients diagnosed by coronary angiography were selected as cases

and 306 non-CHD patients admitted to the hospital in the same period were selected as controls.Serum total cholesterol(TC)

triglycerides(TG)

high density lipoprotein cholesterol(HDL-C)

low-density lipoprotein cholesterol(LDL-C)

apolipoproteinA1(ApoA1)

apolipoprotein B(ApoB)

lipoprotein(a)(LP(a))

and free fatty acids(FFA)were determined and analyzed.Results:The levels of HDL-C in CHD group were significantly lower than that in non-CHD group(P<0.05).In CHD group

HDL-C decreased gradually as the number of coronary artery disease branch increased(P<0.05).Logistic multiple regression analysis

showed low HDL-C level was an independent risk factor for coronary heart disease.Conclusion:HDL-C show significantly negative correlation to the incidence

development and severity of coronary heart disease.TC / HDL-C may have a better predictive value in coronary heart disease diagnosis.