硫酸长春新碱PLGA微囊的制备及体外释放性质研究

凌旭; 张良珂; 李攀; 王海鸥; 冉海涛

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硫酸长春新碱PLGA微囊的制备及体外释放性质研究

技术与方法 | 更新时间：2024-01-17

- 硫酸长春新碱PLGA微囊的制备及体外释放性质研究
- Preparation and in vitro release characteristics of vincristine sulfate-loaded PLGA microcapsules
- 重庆医科大学学报 2009年34卷第12期页码：1696-1698
- 作者机构：
  
  1. 重庆医科大学生命科学研究院
  2. 重庆医科大学附属第二医院超声影像学研究所
- 作者简介：
- 基金信息：
  
  国家自然科学基金资助项目（编号:30770565）;重庆市科委自然科学基金资助项目（编号:CSTC,2008BB5397）;重庆医科大学校级课题（编号:NSFYY200728;XBYB2007098）
- DOI：
  中图分类号： R943
- 纸质出版日期：2009，
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[1]凌旭,张良珂,李攀,王海鸥,冉海涛.硫酸长春新碱PLGA微囊的制备及体外释放性质研究[J].重庆医科大学学报,2009,34(12):1696-1698.

LING Xu, et al. Preparation and in vitro release characteristics of vincristine sulfate-loaded PLGA microcapsules[J]. Journal of Chongqing Medical University, 2009,34(12):1696-1698.
[1]凌旭,张良珂,李攀,王海鸥,冉海涛.硫酸长春新碱PLGA微囊的制备及体外释放性质研究[J].重庆医科大学学报,2009,34(12):1696-1698. DOI：

LING Xu, et al. Preparation and in vitro release characteristics of vincristine sulfate-loaded PLGA microcapsules[J]. Journal of Chongqing Medical University, 2009,34(12):1696-1698. DOI：

摘要

目的:制备硫酸长春新碱乳酸-乙醇酸共聚物[Poly（lactide-co-glycolide）

PLGA]微囊并考察其体外释放。方法:采用W/O/W复乳-溶剂挥干法制备硫酸长春新碱PLGA微囊

考察了内、外水相pH值

PLGA

Span80

NaCl浓度和CH2Cl2挥干方法对微囊包封率的影响

并对其形态、粒径分布和体外释放性质进行了研究。结果:制得的硫酸长春新碱PLGA微囊为球形

表面光滑

平均粒径约为643.1nm

平均包封率为39.5%。结论:采用复乳-溶剂挥干法成功制备硫酸长春新碱PLGA微囊

体外释放表明具有其缓释作用。

Abstract

Objective:To prepare VCR-loaded PLGA microcapsules and study its release characteristics in vitro.Methods:A water-in-oil-in-water double-emulsion/solvent evaporation method was used to prepare VCR-loaded PLGA microcapsules.Some factors affecting entrapment rate of microcapsules

such as pH value of internal and external aqueous phase

PLGA concentration

Span 80 content

NaCl concentration and evaporating way of CH2Cl2

were investigated.In addition

its shape

size distribution and in vitro release properties were studied.Results:Acquired VCR-loaded PLGA microcapsules were spherical and its surface was smooth

the average size of microcapsules were 643.1 nm

and the average entrapment rate was about 39.5%.Conclusion:VCR-loaded PLGA microcapsules were successfully produced according to double-emulsion/solvent evaporation method

and prepared PLGA microcapsules are provided with the role of sustained-release.

关键词

长春新碱PLGA微囊缓释

Keywords

VincristinePLGAMicrocapsulesSustained-release.

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