Objective:To investigate potential correlations between FOXC1 expression and clinicopathologic features of relapsing invasive ductal carcinoma.Methods:FOXC1 protein expression in 42 cases of relapsing invasive ductal carcinoma were investigated with immunohistochemistry.Results:FOXC1 protein expression was observed in invasive ductal carcinoma tissues.Positive FOXC1 expression was revealed in 21(50.0 %)invasive ductal carcinoma.Significant correlation in retrospective study was observed between FOXC1 protein expression and histological grades(P<0.05)as well as drug resistance and PFS after adjuvant chemotherapy(P<0.05).No significant association was shown between FOXC1 protein expression in invasive ductal carcinoma and clinicopathological factors including pathological type
age
primary tumor size
TNBC and non-TNBC
lymph node metastasis
etc(P>0.05).Conclusion:FOXC1 may play a role in malignant degree and drug resistance to relapsing invasive ductal carcinoma.