Objective:To explore the effects of major components in Baiyao on the expression of integrinαvβ3 and CD31 during the process of experimental rabbit fracture healing and understand its significance.Methods:75 New Zealand rabbits were randomly divided into 5 groups in this experiment.After the fracture model of both radius was established by operation

every medical gelatin sponge containing number 1

2

3

4

5 Yunnan Baiyao component was put into all left bone defects of radius separately as 1

2

3

4

5 experiment groups

and the medical gelatin sponge containing nothing was put into all right defects as control groups.The effects of Yunnan Baiyao on the expression of integrinαvβ3 and CD31(The sign of angiogenesis) at different times in the course of bone healing were observed.Results:The expression of integrinαvβ3 and CD31 in number 1-5 Yunnan Baiyao groups was higher than that in control groups at the early stage of fracture healing.Conclusion:Baiyao enhances the expression of integrinαvβ3 and CD31 in the callus

accelerates the vascularization at the broken ends of fractured bone

improves the blood circulation of the fractured extremity

thus promotes the healing of fractured bone.