Objective:To study the expressions of IL-1

TNF-α

SOD and bacterial infection in male rats’ reproductive system after spinal cord injury.Methods:80 SD rats were divided into control group(40 rats) and experimental group(40 rats) randomly.Animal models of spinal cord injury were established by ’Allen’ method.Both groups of rats were fed for 1 day

2 days

4 days

8 days

and 16 days respectively.Then 8 rats’ prostates

testes and epididymises in each group were extirpated for bacterial culture and immunohistochemistry by SABC to detect the expressions of proteins(IL-1

TNF-α

SOD) at each time point.Results:Compared with control group

the risk of E.coli infection in prostate and epididymis was increased significantly in the experimental group(P<0.05);the expressions of testicular IL-1 and TNF-α were increased(P<0.05) and the expression level was the highest in the fourth days after surgery(P<0.05).SOD expression showed no significant difference in the whole reproductive system(P>0.05).Conclusion:Prostate and epididymis of the rat after spinal cord injury are easily infected by bacteria(E.coli);inflammatory response was enhanced in testicular

and the antioxidant activity of reproductive system may be very weak.