Objective:To observe the effects of salvia miltiorrhiza Bunge on the kidney p38MAPK signal channel induced by intestinal ischemia/reperfusion in rats.Methods:Thirty-six male Wistar rats were randomly divided into 3 equal groups:control group

ischemia reperfusion injury group and salvia miltiorrhiza group.Intestinal ischemia reperfusion model was constructed by incarcerating rat SMA.Enzyme-linked immunosorbent assay(ELISA) was used to determine protein content of tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) in kidney tissue.Western blot was used to determine the expression of Phospho-p38 mitogen-activated protein kinase(P-p38MAPKs).Ultraviolet spectrophotometry was used to determine the activity of plasma DAO.HE staining morphology method was used to evaluate injury severity for intestine and kidney.The biochemical analyser was used to test BUN and Cr.Results:Compared with control group

in IR group

intestine and kidney tissue structures were injured seriously;the expressions of p38MAPKs

TNF-α and IL-1β increased significantly

and the content of DAO

BUN and Cr also increased(P<0.01).Compared with IR group

in S group

the expressions of p38MAPKs

TNF-α and IL-1β were reduced significantly;intestine and kidney tissue structures were injured slightly.The content of DAO

BUN and Cr was also reduced(P<0.05).Conclusion:Salvia miltiorrhiza can relieve kidney injury by intestinal ischemia/reperfusion.The mechanism is possibly connected with the inhibition effect on the kidney p38MAPK signal channel to reduce the release of TNF-α and IL-1β.