Objective：To understand the mortality，probability of premature death，potential years of life loss and its distribution of stroke in Chongqing and to provide the suggestion for stroke prevention and control. Methods：Death cases between January 1 and December 31，2016 were reported through death case registry system of national center for disease prevention and control. Death cas－es of stroke（ICD-10：I60-I64） were sorted by international classification of disease（ICD-10）. And it was analyzed to calculate the indicators such as mortality，age-specific standardization mortality rate，proportion，probability of premature death，potential years of life loss. The rate was compared by chi-square test between different genders and areas. Results：The crude mortality and age-specific standardized mortality rate of stroke was 117.35/105 and 63.19/105 respectively in Chongqing，2016. The proportion of stroke death cases was 16.04% of all death cases. The crude mortality and age-specific standardized mortality rate of stroke among male residents was 130.74/105 and 75.72/105 respectively，which was higher than those（103.50/105 and 50.51/105） among female residents signifi－cantly（ χ2=21.710，P=0.000； χ2=27.３４６，P＝0.00０）. The crude mortality and age-specific standardized mortality rate of stroke among rural residents was 137.95/105 and 73.44/105 respectively，which was higher than those（63.54/105 and 35.27/105） among urban resi－dents significantly（ χ2＝53.078，P=0.000； χ2=37.19０，P＝0.00０）. The mortality of stroke before 50 years old was below 50/105 and it in－creased rapidly after 50 years old and reached the peak at age group of 85 years old. The probability of premature death of stroke was 2.88% in Chongqing，2016. The male probability of premature death of stroke（3.74%） was higher than it（1.96%） of the female significantly（ χ2=216.999，P=0.000）. The proba－bility of premature death of stroke in rural area（3.33%） was higher than it（1.61%） in urban area significantly（ χ2=191.043，P=0.000）. Conclusion：The mortality of stroke and probability of pre－mature death of stroke is high in Chongqing. Rural residents and the male are vulnerable population and comprehensive preven－tion and control for stroke should be strengthened.