Objective：To investigate the risk factors of cerebral ischemic injury after endovascular coiling for unruptured intracranial aneurysms（UIA）. Methods：A total of 274 patients suffered from UIA for coil embolization including cerebral ischemic injury were enrolled and divided into negative group（n=165） and cerebral ischemic injury positive group（n=109） according to the MRI or clinical manifestation. Their clinical data were selected and analyzed respectively. Single-factor analysis and logistic regression model were used to analyze the risk factors of cerebral ischemic injury after endovascular coiling for UIA. Results：The total rate of cerebral ischemic injury after endovascular coiling was 40%，34% of the patients with micro-embolism and 6% with neurological dysfunction diseases. Age（OR=2.547，95%CI=1.388 to 4.676，P=0.003），hypertension（OR=2.525，95%CI=1.307 to 4.881，P=0.006），hyperglycemia（OR=1.972，95%CI=1.050 to 3.701，P=0.035），previous stroke history（OR=9.325，95%CI=3.564 to 24.396，P＜0.001），cerebral artery atherosclerosis patches（OR=3.680，95%CI=1.523 to 8.891，P=0.004），intraoperative blood clots（OR=17.031，95%CI=4.042 to 71.756，P＜0.001） and procedure duration（OR=4.097，95%CI=2.126 to 7.894，P=0.007） associated significantly with cerebral ischemic injury and they were the risk factors of cerebral ischemic injury after endovascular coiling for UIA proved by logistic regression model. Conclusion：Age，hypertension，hyperglycemia，previous stroke history，cerebral artery atherosclerosis patches，intraoperative blood clots and procedure duration are the risk factors of cerebral ischemic injury after endovascular coiling for UIA.