Objective：To observe the expression of TNF-α，TWEAK，Fn14 on the treat of tumor cachexia with Shenlingbaizhu powder. Methods：Sixty-four tumor cachexia patients were randomized into treatment group and control group，with thirty-two in each. The control group was given nutritional support and the treatment group was given Shenlingbaizhu powder in addition. The effect was evaluated after 4 weeks. The clinical symptoms，kanrofsky score（KPS），tumor necrosis factor-α（TNF-α），tumor necrosis factor-like weak inducer of apoptosis（TWEAK） and fibroblast growth factor-inducible 14（Fn14） were observed. Results：After treatment，the total effective rates of the Chinese medicine symptom in treatment group and control group were 40.62% and 15.62% respectively，with significant differences between groups（P<0.05）. After treatment，the KPS improvement rate was improved significantly in treatment group（P<0.05）. After treatment，the TNF-α，TWEAK and Fn14 were reduced significally in treatment group（P<0.05）. Conclusion：Shenlingbaizhu powder combined with nutritional support can improve life quality and KPS，decrease TNF-α，TWEAK，Fn14 expres－sion of the tumor cachexia patient. Shenlingbaizhu powder control cancer cachexia maybe due to its regulation of these cytokines.