Objective：To investigate the influencing factors for postoperative quality of life（QOL） in patients with oral and maxillofa－cial malignancies（OMMs）. Methods：A total of 90 patients with oral and maxillofacial malignancies（OMMs） who underwent surgical treatment in a grade A tertiary stomatological hospital in China from January 2016 to March 2018 were selected as subjects. Twenty-nine factors of demography，social psychology，and medical care were collected by on-site interviews，questionnaires，and data mea－surements. The postoperative QOL of patients was evaluated using Functional Assessment of Cancer Therapy-Head and Neck-V4 [FACT-H&N（V4）]. Independent factors for postoperative QOL were analyzed by univariate and multivariate analyses. Results：The univariate and multivariate analyses showed that segmental resection of lower jaw bone（OR=50.897，95%CI=1.319 to 1 964.684，P=0.035），M.D. Anderson Dysphagia Inventory（MDADI） score（OR=1.260，95%CI＝1.086 to 1.462，P=0.002），good social support（OR=677.074，95%CI＝1.166 to 381 787.087，P=0.045） and mini nutritional assessment（MNA） score（OR=28.788，95%CI＝1.151 to 719.778，P=0.041） were independent influencing factors for the QOL of patients with OMMs. Conclusion：It is an effective way to improve the postoperative QOL of patients with OMMs by retaining the continuity of lower jaw bone，reconstructing swallowing func－tion and improving nutritional status and social support.