Objective：To evaluate the efficacy and safety of OB glue in the treatment of pulmonary bullae under CT guide and to seek for the new treating methods. Methods：Sixty patients with pulmonary bullae were enrolled and received preoperative examination. glue was injected into the pulmonary bullae under CT guide. and six minutes walk test were regularly applied after the surgery. The intraoperative and postoperative complications，the changes of thoracic CT and the improvement of pulmonary function were observed. Results：The intraoperative and postoperative complications included chest pain（96.7%），pneumothorax（25%），hemoptysis（21.7%） and fever（21.7%）. The results of thoracic CT showed that the curative rate was 96.7% and the obvious effect rate was 3.4%. Six-minute walk test was performed in 30 cases and the pulmonary function was improved. Conclusion：Percutaneous pulmonary puncture and OB glue in the treatment of pulmonary bullae under CT guide is a secure and efficient therapy.