Objective：To compare the efficacy of spasmolytic cocktail composed of Nitroglycerin，Verapamil，Diltiazem and Isosorbide mononitrate in reducing the incidence of radial atery spasm in patients undergoing transradial coronary interventions. Methods：Pa－tients enrolled were randomly divided into three groups. After successful cannulation and sheath insertion into radial arteries，patients in group A received intra-aterial Nitroglycerin 200 μg and Verapamil 200 μg，patients in group B received Isosorbide mononitrate 5 mg and Verapamil 200 μg，patients in group C received Nitroglycerin 200 μg and Diltiazem 2.5 mg. Then the incidence of spasm was determined. Results：There were significant statistical differences between groups A and C（P<0.05）. Conclusion：Intra-arterial pre－medication with cocktail composed of 200 μg Nitroglycerin and 200 μg Verapamil is more effective in preventing radial spasms dur－ing percutaneous coronary interventions through radial artery.