Objective：To investigate the diagnostic value of capsule endoscopy（CE） in patients with gastrointestinal diseases and to guide the reasonable application of capsule endoscopy. Methods：The clinical data of 251 patients underwent OMOM capsule en－doscopy with telephone follow-ups were retrospectively analyzed. Results：There were significant differences in the patients with ob－scure gastrointestinal bleeding between the elderly group and the non-elderly group（45.3% vs. 26.7%，P=0.005 7）. Meanwhile，there were significant differences in the patients with abdominal pain or diarrhea between the elderly group and the non-elderly group （54.7% vs. 71.1%，P=0.015 9）. The rate of complete small-bowel examination was 93.2%. The gastric transit time in complete small-bowel examination was significantly shorter than that in the non-complete small-bowel examination group（47.4 min vs. 66.2 min，P=0.043 2）. CE showed that the risk of non-complete small-bowel examination was bile reflux（OR=4.49）. Metoclopramide（10 mg，intramuscular injection） did not exerted effect on the small bowel transit time（298.3 min vs. 313.3 min），but it can reduce the gas－tric transit time of the capsule. The positive detection rate of small bowel diseases was up to 94.9% in the patients with obscure gas－trointestinal bleeding（75/79），most commonly in vascular malformation（31.6%）. The positive detection rate was 44.4%（8/18） for high risk population of small intestine ancylostomiasis；85.7%（144/168）for abdominal pain or diarrhea group with mucosal inflammation was frequent seen（26.8%）. There were no significant differences in the detection rate of small bowel diseases among the elderly group，the children group and the middle-aged group（89.1% vs. 100% vs. 91.7%）. The detection rate of small bowel diseases was significantly higher in the high definition capsule endoscopy group than that in the 06 capsule endoscopy group（96.7% vs. 86.4%，P=0.032 3）. All patients were well tolerated and the capsule and successfully discharged. Conclusion：The manipulation of capsule endoscopy is simple，safe and effective and it is of important value in the diagnosis of small intestinal diseases. Metoclopramide （intramuscular in－jection） can improve the complete rate. Parasite elimination can be done before CE exam for high risk population of small intestine ancylostomiasis.