Objective：To systematically review the advantages of minimally invasive percutaneous nephrolithotomy（MPCNL）. Meth－ods：Randomized controlled trials of minimally invasive and standard percutaneous nephrolithotomy were retrieved and their included references were investigated. Data analysis of literatures meeting the inclusion criteria was performed with the Cochrane Collaboration’s RevMan 5.0 software. Results：Five literatures were finally retrieved after screening and a total of 726 patients were included for Meta-analysis. Results showed that the patients in experimental group had the following features as compared with those in control group：①remarkable improvement of the calculi clearance rate（95%CI[1.00-1.21]，P=0.04）；②obvious decrease of the complication inci－dence（95%CI[0.40-0.79]，P=0.000 9）. Conclusions：With higher clearance rate，lower complication incidence，MPCNL is safer and more effective than standard percutaneous nephrolithotomy in treating upper urinary tract calculi. As the literatures and samples in this study are limited，high quality trials with lager sample and longer follow-up are recommended in order to provide reliable evidences for clinical application of MPCNL.