Objective：To systematically review and evaluate the effctiveness of ultrasonic and monopolar electrosurgical scalpel in la－paroscopic cholecystectomy. Methods：Randomized clinical trials related with ultrasonic or monopolar electrosurgical scalpel used in laparoscopic cholecystectomy with adult patients of symptomatic gallstone disease were searched from PubMed，Cochrane library，EMbase，Ovid，CNKI，WanFang and VIP. Two reviewers independently assessed the quality and extracted the data. All data were ana－lyzed by using RevMan 5.1. Results：Ten trials with a total of 1 199 patients met the inclusion criteria（604 patients in ultrasonic scalpel group and 595 patients in electrosurgical scalpel group）. Meta analysis showed that compared with those in monopolar electro－surgical scalpel group：①average operating time was significantly shorter in ultrasonic scalpel group（WMD（-11.75），95%CI[-16.61，-6.89]，P<0.000 01）；②gallbladder perforation rate was lower in ultrasonic scalpel group（RR 0.40，95%CI[0.31，0.51]，P<0.000 01）；③average intraoperative blood loss was less in ultrasonic scalpel group（WMD（-24.38），95%CI[-40.88，-7.89]，P=0.004）；④av－erage hospital duration was shorter in ultrasonic scalpel group（WMD（-0.40），95%CI[0.68，-0.11]，P=0.006）；⑤visual ana－logue scale scores at 24 h postoperatively was significantly lower in ultrasonic scalpel group（WMD（-1.12），95%CI[-1.23，-1.01]，P<0.000 01）；⑥the postoperative complication risk was lower in ultrasonic scalpel group（RR 0.47，95%CI[0.25，0.88]，P=0.02）. How－ever，there was no statistical difference in rate of conversion to open surgery between the two groups（RR 0.54，95％CI[0.23，1.27]，P=0.16）. Conclusions：Ｒesults show that ultrasonic scalpel can shorten the operating time，reduce gallbladder perforation rate，blood loss，postoperative 24 h visual analogue scale scores and postoperative complication rate for patients with non-acute calculous chole－cystitis underwent elective laparoscopic cholecystomy. Because of the limits of the sample and quality of included studies，this con－clusion has to be verified with more strictly designed large scale randomized controlled trials.