Objective：To investigate the differences in clinical efficacy，complication and safety between transurethral resection of prostate（TURP） and bipolar plasmakinetic resection of the prostate（PKRP） in the treatment of benign prostatic hyperplasia（BPH）. Methods：Totally 560 cases of BPH from January 2009 to December 2011 were divided into TURP group and PKRP group. General conditions，operation conditions，clinical efficacy and complications of two groups were analyzed. Results：There was no significant difference in baseline data between the two groups（P >0.05）. Operative time（t=8.046，P=0.000），intraoperative bleeding（t=16.653，P=0.000） and time of urethral catheterization（t=7.701，P=0.000） of PKRP group were significantly less than those TURP group（P<0.05）. International prostate symptom score（IPSS）（t=62.092，P=0.000），quality of life（QOL）（t=72.355，P=0.000），maximum flow rate（Qmax） （t=73.993，P=0.000） were significantly improved in TURP group after surgery compared with those before surgery（P<0.05）. IPSS（t=77.777，P=0.000），QOL（t=82.038，P=0.000），Qmax（t=89.860，P=0.000） were significantly improved in PKRP group after surgery compared with those before surgery（P<0.05），but there was no significant difference in above indicators between the two groups（P >0.05）. Transurethral resection syndrome（TURS），hemodynamic fluctuations，intraoperative blood loss etc were significantly higher in TURP group than in PKRP group（P<0.05）. Conclusions：PKRP and TURP have similar clinical efficacy in the treatment of BPH. PKRP has advantages in shorter operative time，less bleeding and few complications in the treatment of BPH，but long-term therapeutic effect of PKRP needs further follow-up.