Objective：To analyze the risk factor，etiology，pathogenesis，clinical manifestations and MRI feature of corpus callosal in－farction. Methods：Retrospective analysis was undertaken in 13 cases with corpus callosal infarction. Results：Risk factors of corpus callosal infarction included hypertension，diabetes mellitus，hyperlipidemia.Large arteries atherosclerosis and it’s potential mechanisms involved mainly in the corpus callosal infarction. Clinical manifestations were complex and diverse without specificity.Typical corpus callosum transection syndrome was not observed.Lesions were located mainly in the body and splenium of corpus callosum，always involving cerebral infarction of other parts in the posterior circulation blood supply area. Conclusions：Clinical manifestations of corpus callosalinfarction vary according to different lesion sites. Hypertension，diabetes mellitus，hyperlipidemia are the substantially important risk factors.Large arteries atherosclerosis and it’s potential mechanisms involve in the occurrence of the disease. MRI is helpful to locate clinically and treat corpus callosal infarction.