LIU Yong, CHEN Xiaoqian, LI Hang, et al. Expression and forensic significance of interleukin-4,interleukin-13 and immunoglobulin E in guinea pigs died of anaphylactic shock[J]. Journal of Chongqing Medical University, 2013,36(11):1322-1324.
LIU Yong, CHEN Xiaoqian, LI Hang, et al. Expression and forensic significance of interleukin-4,interleukin-13 and immunoglobulin E in guinea pigs died of anaphylactic shock[J]. Journal of Chongqing Medical University, 2013,36(11):1322-1324.DOI:
Objective:To establish animal model of guinea pig anaphylactic shock,to explore the expression of interleukin-4(IL-4),interleukin-13(IL-13) and immunoglobulin E(IgE) in guinea pig serum and to provide scientific and objective evidences for clinical and medicolegal diagnosis of anaphylactic shock as well. Methods:Totally 30 guinea pigs were died of anaphylactic shock were divided into experiment group(n=20) and control group(n=10). ELISA method was used to detect IL-4、IL-13 and IgE by extracting serum of guinea pigs in experiment group and control group. Results:Serum IL-4 level in experimental group was higher than that in control group,P=0.000;serum IL-13 level in experimental group was higher than that in control group,P=0.000;serum IgE level in experi-mental group was higher than that in control group,P=0.000. Conclusions:Serum levels of IL-4,IL-13 and IgE in experiment group are obviously higher those in control group,which provides evidences for anaphylactic shock forensic identification and clinical diag-nosis.
关键词
豚鼠过敏性休克白细胞介素4白细胞介素13免疫球蛋白E法医学
Keywords
guinea piganaphylactic shockinterleukin-4interleukin-13immunoglobulin Eforensic medicine