Objective：To study the effects of recombinant human acidic fibroblast growth factor（rhaFGF） and recombinant human epi－dermal growth factor（rhEGF） on wound healing of rabbits’ ears with full-thickness skin injury. Methods：Models of rabbits’ ears with full-thickness skin injury were made and randomly divided into four groups：group A（rhaFGF 60 U/cm2+rhEGF 20 U/cm2），group B（rhaFGF 60 U/cm2），group C（recombinant bovine basic fibroblast growth factor 60 U/cm2）and group D（equivalent normal saline）. The reagents in the brackets were given every two days. Wound healing rate and time were respectively recorded at different time points through hyaline membrane tracing. Wound tissues were obtained on the 3rd，7th and 14th d to evaluate wound healing state through HE staining. Results：Wound healing time was statistically different between group A（（13.33±0.12） d） and other groups（P＜0.05）. Wound healing rate was also statistically different between group A and other groups. HE staining showed that on the 3rd and 7th d after modeling，growth of fibroblasts and capillary was more vibrate in group A and C than that in group B and D. On the 14th d after modeling，wound was almost healed in group A and fibroblasts and capillary of group A were relatively rare compared with those in other groups. Conclusions：rhaFGF combined with hEGF can promote wound healing in rabbits’ ears. Combination of the two drugs can stimulate the growth of granulation tissue，capillary formation and re-epithelialization. In the later stage of wound healing，capillary and fibroblasts grow slower，which may reduce the possibility of scar formation.