ABCA1基因R1587K多态性与冠心病遗传易感性的系统评价

董 渊; 冉启军; 魏泽红; 邓小冬; 聂倩云; 唐任宽

您当前的位置：

首页 >

文章列表页 >

ABCA1基因R1587K多态性与冠心病遗传易感性的系统评价

循证医学 | 更新时间：2023-12-18

- ABCA1基因R1587K多态性与冠心病遗传易感性的系统评价
- Association between ABCA1 gene R1587K polymorphism and coronary heart disease susceptibility：a systematic review
- 重庆医科大学学报 2015年40卷第10期页码：1312-1317
- 作者机构：
  
  1. 重庆医科大学基础医学院法医学教研室,重庆,400016
  2. 四川省宣汉县人民医院心内科，宣汉,636150
  3. 川北医学院法医学系,南充,637000
- 作者简介：
- 基金信息：
- DOI：
  中图分类号：
- 纸质出版日期：2015，
扫描看全文
董渊, 冉启军, 魏泽红, 等. ABCA1基因R1587K多态性与冠心病遗传易感性的系统评价[J]. 重庆医科大学学报, 2015,40(10):1312-1317.

Dong Yuan, Ran Qijun, Wei Zehong, et al. Association between ABCA1 gene R1587K polymorphism and coronary heart disease susceptibility：a systematic review[J]. Journal of Chongqing Medical University, 2015,40(10):1312-1317.
董渊, 冉启军, 魏泽红, 等. ABCA1基因R1587K多态性与冠心病遗传易感性的系统评价[J]. 重庆医科大学学报, 2015,40(10):1312-1317. DOI：

Dong Yuan, Ran Qijun, Wei Zehong, et al. Association between ABCA1 gene R1587K polymorphism and coronary heart disease susceptibility：a systematic review[J]. Journal of Chongqing Medical University, 2015,40(10):1312-1317. DOI：

摘要

目的：探讨三磷酸腺苷结合盒转运蛋白A1（ATP binding casette transporter A1，ABCA1）基因R1587K多态性与冠状动脉粥样硬化性心脏病（coronary heart disease，CHD）遗传易感性的关系。方法：计算机检索PubMed、Web of Science、中国学术期刊全文数据库（CNKI）、万方数据库和维普数据库，检索时间截止2014年7月，获取有关ABCA1基因R1587K多态性与冠心病遗传易感性的病例-对照研究。以OR 值及其95%CI为效应指标，运用Stata 11.0软件在异质、同质、显性和隐性遗传模式下进行Meta分析。结果：共纳入5个研究（实验组2 032例和对照11 492例）。Meta分析结果显示ABCA1基因R1587K多态性与冠心病遗传易感性在异质和显性遗传模式下均存在明显的统计学意义（异质模式：OR=1.140，95%CI=1.028~1.266，POR=0.014；显性模式：OR=1.124，95%CI=1.017~1.243，POR=0.022）；按种族进行亚组分析其结果显示该遗传易感性在高加索人群中较显著。结论：ABCA1基因R1587K多态性可能与高加索人群冠心病遗传易感性有关，需开展更多高质量、大样本的随机对照试验加以验证。

Abstract

Objective：To investigate the association between ATP binding casette transporter A1（ABCA1） gene R1587K polymorphism and coronary heart disease susceptibility. Methods：Literature was retrieved in electronic databases covering PubMed，Web of Science，CNKI，WanFang and VIP up to Jun，2014 to collect the case-control studies on ABCA1 gene R1587K polymorphism and coronary heart disease susceptibility. The odds ratios（ORs） and 95% conidence intervals（CIs） were taken as the effect indexes，either the fixed or random effect model was applied to conduct Meta-analysis by Stata 11.0 software in heterozygote，homozygote，dominant，and recessive genetic models，respectively. Results：A total of 5 case-control studies were identified，involving 2 032 cases and 11 492 controls. The current Meta-analysis showed that the AB－CA1 gene R1587K polymorphism was significantly associated with coronary heart disease under homozygote and dominant genetic model（homozygote：OR=1.140，95%CI=1.028~1.266，POR=0.014；dominant：OR=1.124，95%CI=1.017~1.243，POR=0.022）. Subgroup analysis results by ethnicity were significantly associated with Caucasian. Conclusion：The current Meta-analysis suggests that ABCA1 gene R1587K polymorphism might be associated with coronary heart disease susceptibility in Asian. Further studies are needed to val－idate the above conclusion.

关键词

三磷酸腺苷结合盒转运蛋白A1单核苷酸多态性遗传易感性冠心病Meta分析

Keywords

ATP binding casette transporter A1single nucleotide polymorphismgenetic susceptibilitycoronary heart diseaseMeta-analysis

references

浏览量

331

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

ADAMTS1基因多态性与冠心病的相关性研究

冠心病患者sST2、Gal-3水平与心肌纤维化的相关性研究

斑点追踪技术评估升主动脉弹性与冠心病患者冠脉病变的相关性研究

阿加曲班治疗急性缺血性卒中疗效及安全性的系统评价及Meta分析

针刺结合多奈哌齐治疗阿尔茨海默病疗效的Meta分析