Objective To analyze the expressions and clinical significance of vasohibin 1(VASH-1) and leucinerich repeatcontaining Gproteincoupled receptor 5 (LGR5) in oral squamous cell carcinoma(OSCC). Methods The expressions of VASH1 and LGR5 in cancer tissues and adjacent tissues of 87 patients with oral squamous cell carcinoma treated in Tangshan union medical college hospital from March 2016 to March 2018 were detected by immunohistochemical SP method.The relationship between the expressions of VASH1 and LGR5 and the clinicopathological features of oral squamous cell carcinoma patients was analyzed

and the correlation between VASH1 and LGR5expression in oral squamous cell carcinoma tissues was analyzed. Results The positive rates of VASH1 and LGR5 in oral squamous cell carcinoma tissues were significantly higher than those in adjacent tissues(P<0.05).The positive rates of VASH1 and LGR5 of patients with pathological grade Ⅰ

tumor diameter≤2 cm

TNM stage Ⅰ to Ⅱ

and without lymph node metastasis were significantly lower than those of patients with pathological grade Ⅱ to Ⅲ

tumor diameter>2 cm

TNM stage Ⅳ to Ⅳ

and had lymph node metastasis(P<0.05).Spearman correlation showed that there was a positive correlation between the expressions of VASH1 and LGR5 in oral squamous cell carcinoma (Rs=0.723

P=0.000). Conclusion The expressions of VASH1 and LGR5 in oral squamous cell carcinoma are significantly higher

and the levels of VASH1 and LGR5 are closely related to tumor diameter

pathological grade and lymph node metastasis

and the expression of VASH1 is positively correlated with the expression of LGR5.