Objective To investigate the effect of a personalized rational drug use monitoring system in intensive monitoring of drug management in hospitals. Methods A self-developed personalized rational drug use monitoring system was used to review the medical orders of drugs under intensive monitoring in the Ninth People’s Hospital of Chongqing

and compared with a manual review. Results After the use of the personalized rational drug use monitoring system

the proportion of medical order reviews of intensive monitoring drugs increased from 5.60% to 75.58%

the feedback cycle shortened from 3 months to 1 month; the proportion of irrational drug use decreased from 10.03% to 5.65% after cooperating with intervention measures; the proportion of intensive monitoring drugs used in the whole hospital decreased from 8.52% to 4.79%; the number of intensive monitoring drugs used per capita for hospitalized patients decreased from 610.20 RMB to 349.46 RMB. Conclusion Personalized rational drug use monitoring system plays an effective role in the intensive monitoring of drug management

and the software will continue to be improved in the future to promote the rational use of intensive monitoring of drugs.