Objective To explore the application effect of the whole-course quality control-based blood transfusion test process in blood transfusion therapy. Methods A total of 122 patients who received blood transfusions in the First People’s Hospital of Shangqiu from October 2019 to October 2021 were selected as the study subjects. They were assigned to the observation group and the control group by the random number table

with 61 cases in each group. The routine blood transfusion test process was used for patients in the control group

and the whole-course quality control-based blood transfusion test process was implemented for patients in the observation group on the basis of the control group. The incidence of adverse events of blood transfusion

quality of blood transfusion

and satisfaction with diagnosis and treatment services were compared between the two groups. Results The incidence of adverse events of blood transfusion in the observation group was 1.64%（1/61）

which was lower than that in the control group（11.48%

7/61）

but the difference was not statistically significant（χ2=3.344

P=0.067）. The scores of 5 blood transfusion quality items in the observation group were significantly higher than those in the control group（P <0.05）. The patient satisfaction rate in the observation group was 95.08%（58/61）

which was significantly higher than that in the control group（81.97%

50/61; χ2=5.164

P=0.023）. Conclusion The application of the whole process quality control-based blood transfusion test process in blood transfusion therapy showed marked effects

which helps to reduce the risk of adverse events during blood transfusion therapy

increase the quality of blood transfusion and improve patient satisfaction.