Objective To investigate the effect of Shensong Yangxin capsule combined with amiodarone on serum inflammatory factors and myocardial injury markers in patients with atrial fibrillation after radiofrequency ablation. Methods Patients with atrial fibrillation who underwent radiofrequency ablation at Central Hospital of Jinzhou from March 2016 to March 2021 were selected as the study subjects. The patients were randomly allocated to the observation group and control group

with 265 cases in each group. Patients in the control group were treated with amiodarone hydrochloride on the day after surgery and patients in the observation group were treated with Shensong Yangxin capsule on the basis of the treatment in the control group. Left ventricular ejection fraction（LVEF）

left atrial diameter（LAD）

high-sensitivity C-reactive protein（hs-CRP）

interleukin-6（IL-6）

tumor necrosis factor-α（TNF-α）

Creatine kinase-MB（CK-MB）

Cardiac Troponin I（c TnI）

and creatine kinase（CK） levels were compared between the two groups at 1 d and 3 months after surgery. The incidence and recurrence of adverse reactions within 3 months after the operation were compared between the two groups. Results At 3 months after the operation

LVEF in the two groups was significantly higher than that at 1 d after the operation

with the observation group higher than that in the control group（P<0.05）. At 3 months after the operation

LAD in the two groups was significantly smaller than that at 1 d after the operation

with the observation group smaller than the control group（P<0.05）. At 3 months after the operation

the levels of hs-CRP

IL-6

TNF-α

CK-MB

CTnI

and CK in the two groups were significantly lower than those at 1 d after the operation

with the observation group lower than the control group（P <0.05）. There was no significant difference in the overall incidence of adverse reactions between the two groups（P>0.05）. The recurrence rate in the observation group was significantly lower than that in the control group（P<0.05）. Conclusion Shensong Yangxin capsule in combination with amiodarone can effectively prevent the recurrence

improve cardiac function

and reduce the levels of serum inflammatory factors and myocardial injury markers in patients with atrial fibrillation after radiofrequency ablation

with a high safety profile

which hold much promise for clinical application.