Objective To investigate the effect of autologous blood transfusion technology on coagulation function

inflammatory factors and immune function in patients undergoing hip replacement under general anesthesia. Methods A total of 96 patients who underwent hip replacement under general anesthesia in a hospital in Mianyang City from February 2018 to January 2020 were selected as subjects. They were assigned to the control group（n=48） and the observation group（n=48） by the random number table method. The control group received routine perioperative management intervention

while the observation group received autologous blood transfusion technology intervention. The general operating conditions of the patients in the two groups were compared. The coagulation functions [prothrombin time（PT）

fibrinogen（FIB）

activated partial thrombostin time（APTT）

inflammatory factors [interleukin-6（IL-6）

interleukin-10（IL-10） and tumor necrosis factor-α（TNF-α）] and immune function indicators [immunoglobulin A（IgA）

immune globulin G（IgG） and immunoglobulin M（IgM）] were compared. Results There was no significant difference in operation time

intraoperative blood loss and intraoperative fluid replacement volume between the two groups（P>0.05）. The amount of allogeneic blood transfusion in the observation group was lower than that in the control group

and the difference was statistically significant（P<0.05）. The average volume of autologous blood transfusion in the observation group was 281.04±53.17 mL. At 7 d post-operation

the PT and APTT of the two groups were shorter than those at 1 d pre-operation

and the observation group was lower than the control group

with statistical significance（P<0.05）. At 7 d post-operation

the FIB of both groups was higher than that at 1 d pre-operation

and the observation group was higher than the control group

with statistical significance（P<0.05）. At 7 d post-operation

the levels of IL-6 and TNF-α in both groups were lower than those at 1 d pre-operation

and the observation group was lower than the control group

with statistical significance（P<0.05）. At 7 d post-operation

the levels of IL-10 in the two groups were higher than those at 1 d pre-operation

and the observation group was higher than the control group

with statistical significance（P<0.05）. At 7 d post-operation

the levels of IgA

IgM and IgG in the two groups were lower than those at 1 d pre-operation

and the differences were statistically significant（P<0.05）. At 7th d post-operation

the levels of IgA

IgM and IgG in the observation group were higher than those in the control group

and the differences were statistically significant（P<0.05）. Conclusion Autologous blood transfusion technology can effectively reduce the amount of allogeneic blood transfusion in patients undergoing hip replacement under general anesthesia

improve the coagulation function and immune function of patients

and reduce the inflammatory response. These benefits justify a wider application of this technique in clinical practice.