Objective To investigate the effect of anti-mullerian hormone（AMH） and insulin-like growthfuctors（IGFs） on postoperative pregnancy in patients with endometriosis complicated with infertility. Methods A total of 64 infertile patients with endometriosis who underwent surgery in a hospital in Guangzhou from March 2019 to March 2020 were selected as the study subjects. The patients were assigned to the pregnant group（n=41） and the non-pregnant group（n=23） following the spontaneous pregnancy 1 year after the operation. The patients in the pregnancy group were divided into 3 subgroups following postoperative spontaneous pregnancy time: spontaneous pregnancy group within 4 months after operation（group A）

spontaneous pregnancy group within 5-8 months after operation（group B）

and spontaneous pregnancy group within 9-12 months after operation（group C）

with 15 patients in group A

16 patients in group B and 10 patients in group C. Preoperative and postoperative AMH and IGFs levels were compared between pregnant and non-pregnant patients; preoperative and postoperative AMH and IGFs levels were compared between subgroups A

B

and C. Correlation analysis was performed between preoperative AMH and IGFs levels and postoperative pregnancy time. Results The levels of AMH and IGFs before and after operation in the pregnant group were significantly higher than those in the non-pregnant group（P <0.05）. There were significant differences in AMH and IGFs levels among the three subgroups（P<0.05）. With the increase in spontaneous pregnancy time after operation

the levels of AMH and IGFs gradually decreased. The levels of AMH and IGFs remained the highest in group A

and the lowest in group C

and the differences were statistically significant（P<0.05）. There was a negative correlation between preoperative AMH（r=-0.52

P<0.05） and postoperative IGFs of spontaneous pregnancy time（r=-0.46

P<0.05）. Conclusion The preoperative levels of AMH and IGFs in patients with endometriosis complicated with infertility significantly affect the spontaneous pregnancy rate and spontaneous pregnancy time after operation. The higher the levels of AMH and IGFs

the shorter the spontaneous pregnancy time after operation.