Objective To explore the application of micro-implant anchorage in the treatment of dental deformity. Methods A total of 80 patients with deformities admitted to a hospital in Henan Province from December 2019 to December 2020 were selected as subjects

who were assigned to an observation group and a control group via the random number table method

with 40 cases in each group. Patients in the control group received traditional orthodontic treatment. The patients in the observation group received micro-implant anchorage. The efficacy was compared between the two groups at 3 months after treatment; the masticatory function and the levels of nitric oxide（NO）

intercellular adhesion molecule-1（ICAM-1）

and matrix metalloproteinase-2（MMP2） in the gingival sulcus fluid were compared between the two groups before and after treatment at 3 months. Results The total effective rate of treatment for patients in the observation group was 95.00%

which was higher than that in the control group（72.50%）

with statistically significant differences（P <0.05）. Before treatment

there was no statistically significant difference in the occlusal force and masticatory efficiency between the 2 groups（P>0.05）. At 3 months after treatment

the occlusal force of patients in the 2 groups was greater than that before treatment

with the observation group greater than the control group

and the difference was statistically significant（P<0.05）. The masticatory efficiency of patients in the 2 groups was higher than that before treatment

with the observation group higher than the control group

and the difference was statistically significant（P<0.05）. Before treatment

there was no statistically significant difference in the levels of NO

ICAM-1 and MMP2 in the gingival sulcus fluid between the 2 groups of patients（P>0.05）. At 3 months after treatment

the levels of NO

ICAM-1

and MMP2 in the gingival sulcus fluid of the patients in the 2 groups were higher than those before treatment

with the observation group lower than in the control group

and the differences were all statistically significant（P<0.05）. The incidence of adverse reactions in the observation group was lower than that in the control group

and the difference was statistically significant（P<0.05）. Conclusion Micro-implant anchorage can effectively improve the masticatory function in patients with dental deformities and reduce the inflammatory reaction of the gingival sulcus

and the incidence of adverse reactions is low

with a favorable safety profile. These advantages justify a wider application of this procedure clinically.