Objective To explore the intervention effect of multi-maintenance care combined with blue light irradiation under developmental care in neonates with pathological jaundice.Methods Three hundred and twenty children with pathological jaundice admitted to a hospital in Zhangye City from January 2019 to January 2021 were selected as subjects and assigned to a control group and an observation group using the random number table

with 160 cases in each group.The children in the control group received conventional care combined with blue light irradiation

and the children in the observation group received multi-maintenance care combined with blue light irradiation under developmental care.The clinical efficacy

occurrence of adverse reactions and serum bilirubin level before and after treatment were compared between the two groups.Results The levels of total bilirubin（TBIL）

direct bilirubin（DBIL）

and indirect bilirubin（IBIL） in the two groups after treatment were lower than those before treatment

and the observation group had lower levels than the control group

with statistically significant differences（P<0.05）.The total effective rate of children in the observation group was 93.13%

which was higher than that in the control group（76.25%）

and the difference was statistically significant（P<0.05）.The incidence of adverse reactions in the observation group was 5.00%

which was lower than that in the control group（14.38%）

and the difference was statistically significant（P<0.05）.Conclusion The multi-maintenance care in combination with blue light irradiation under developmental care can effectively reduce serum bilirubin levels

improve clinical efficacy and reduce the risk of adverse reactions in children with pathological jaundice.