Objective To investigate the efficacy of phentolamine in combination with posterior pituitary hormone in the treatment of bronchiectasis.Methods Eighty patients with bronchiectasis admitted to a hospital in Pingdingshan from February 2018 to February 2021 were selected as subjects and divided into a control group（n=40） and an experimental group（n=40） using the random number table.The patients in the control group were treated with posterior pituitary hormone and the patients in the experimental group were treated with phentolamine combined with posterior pituitary hormone

and both groups were continuously treated for 5 d.The clinical efficacy of the two groups was compared;the improvement time of symptoms（time to disappearance of fever

time to relief of cough and hospitalization） and the occurrence of adverse reactions such as chest tightness

dizziness and gastrointestinal reactions during the treatment were compared;the St.George’s Respiratory Questionnaire（SGRQ） scores before and after treatment were compared between the two groups.Respiratory Questionnaire（SGRQ） scores

blood gas index [partial pressure of oxygen（Pa O2）

oxygen saturation（Sa O2）

oxygenation index（Pa O2/Fi O2）] and quality of life were compared between groups before and after treatment.Results The total effective rate in the experimental group was 97.5%

which was higher than that in the control group（77.5%）

and the difference was statistically significant（P<0.05）.The incidence of adverse reactions during treatment was 5.0% in the experimental group

lower than that in the control group（20.0%）

and the difference was statistically significant（P<0.05）.After treatment

the scores of SGRQ in all dimensions and total scores of patients in the 2 groups decreased compared with pre-treatment

and the experimental group had lower scores than the control group

and the differences were statistically significant（P<0.05）.The time to fever disappearance

cough relief time and hospitalization time were shorter in the experimental group than those in the control group

and the differences were statistically significant（P<0.05）.After treatment

Pa O2

Sa O2 and Pa O2/Fi O2 levels raised compared with post-treatment

and the levels were higher in the experimental group than those in the control group

with statistically significant difference（P<0.05）.After treatment

the quality of life scores of patients in both groups increased compared with pre-treatment

with the scores in the experimental group higher than those in the control group

and the difference was statistically significant（P<0.05）.Conclusion The phentolamine in combination with posterior pituitary hormone is effective in the treatment of bronchiectasis

which can significantly reduce adverse effects

shorten the improvement time of symptoms

improve blood gas index and quality of life

and is worth promoting in clinical practice.