Objective To study the effect of integrated medical-nursing care model on negative emotions and prognosis of ovarian cancer patients. Methods Eighty cases of ovarian cancer patients admitted to a hospital in Luoyang from November 2019 to December 2020 were selected as study subjects and divided into control group and study group using a random number table

both with 40 cases. Patients in the control group were given conventional care

while patients in the study group received integrated medical-nursing care

and patients in both groups were cared for until discharge and followed up for 6 months. The patients in the two groups were compared in terms of satisfaction with care at discharge

compliance with chemotherapy at 6 months of follow-up

Self-rating anxiety scale（SAS） and Self-rating depression scale（SDS） scores before and after care

and chemotherapy complications during care. Results At the time of discharge

the satisfaction scores of patients in the study group were higher than those in the control group

and the differences were statistically significant（P<0.05）. At 6-month follow-up

the overall chemotherapy compliance rate of patients in the study group was 90.00%

which was higher than that of the control group（65.00%）

with statistically significant differences（P<0.05）. Before care

there was no statistically significant difference between the SAS and SDS scores of patients in the 2 groups（P>0.05）; at the 6-month follow-up

the SAS and SDS scores of patients in the 2 groups were lower than before care

and the study group was lower than the control group

with statistically significant differences（P<0.05）. During the care period

the incidence of chemotherapy complications was 7.50% in the study group

which was lower than 30.00% in the control group

and the difference was statistically significant（P<0.05）. Conclusion The integrated medical-nursing care model can effectively improve chemotherapy compliance and nursing satisfaction of ovarian cancer patients

relieve their negative emotions

shorten recovery time and improve disease prognosis

and therefore

it is worthy of clinical application.