Objective To explore the effect of early clustering nursing intervention in the nursing of patients with lung infection after radical esophageal cancer（EC） surgery.Methods Eighty patients with lung infection after radical surgery for EC admitted to a hospital in Henan province from January 2019 to December 2020 were selected for the study

and the patients were divided into a study group（n=40） and a control group（n=40） using the random number table method.Patients in the control group received conventional care

and patients in the study group received early clustrering care on the basis of the control group

and the intervention time was 2 weeks in both groups.The scores of self-rating depression scale（SDS）

self-rating anxiety scale（SAS）

Pittsburgh sleep quality index（PSQI） and activities of daily living（ADL） assessment were compared before and after the intervention;FEV1

MMEF and FEV1/FVC levels were compared before and after the intervention.Results After the intervention

the SDS

SAS and PSQI scores of the 2 groups were lower than those before the intervention

and the study group was lower than the control group

and the differences were statistically significant（P<0.05）.After the intervention

the scores for the instrumental and basic activities and the total scores in ADL were higher in the 2 groups than before the intervention

and the study group was higher than the control group

and the differences were statistically significant（P<0.05）.After the intervention

FEV1

MMEF and FEV1/FVC were greater in the 2 groups than before the intervention

and the study group was greater than the control group

and the differences were statistically significant（P<0.05）.Conclusion The application of early clustering nursing intervention in patients with lung infection after radical EC surgery is effective in reducing patients’ negative emotions

improving their sleep quality and lung function

and is worthy of clinical application.