不同严重程度高胆红素血症新生儿血清AST、CK-MB、LDH、BUN、TBiL水平的表达及临床意义

师淑锋; 李晶; 王孝勇

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不同严重程度高胆红素血症新生儿血清AST、CK-MB、LDH、BUN、TBiL水平的表达及临床意义

临床医学 | 更新时间：2022-11-04

- 不同严重程度高胆红素血症新生儿血清AST、CK-MB、LDH、BUN、TBiL水平的表达及临床意义
- Expression and clinical significance of AST,CK-MB,LDH,BUN and TBiL levels in neonates with different severity of hyperbilirubinemia
- 保健医学研究与实践 2022年19卷第1期页码：72-75
- 作者机构：
  
  郑州大学附属儿童医院新生儿内科
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R722.1
- 纸质出版日期：2022，
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师淑锋, 李晶, 王孝勇. 不同严重程度高胆红素血症新生儿血清AST、CK-MB、LDH、BUN、TBiL水平的表达及临床意义[J]. 保健医学研究与实践, 2022,19(1):72-75.

Shi Shufeng, Li Jing, Wang Xiaoyong. Expression and clinical significance of AST,CK-MB,LDH,BUN and TBiL levels in neonates with different severity of hyperbilirubinemia[J]. Health Medicine Research and Practice, 2022,19(1):72-75.
师淑锋, 李晶, 王孝勇. 不同严重程度高胆红素血症新生儿血清AST、CK-MB、LDH、BUN、TBiL水平的表达及临床意义[J]. 保健医学研究与实践, 2022,19(1):72-75. DOI：

Shi Shufeng, Li Jing, Wang Xiaoyong. Expression and clinical significance of AST,CK-MB,LDH,BUN and TBiL levels in neonates with different severity of hyperbilirubinemia[J]. Health Medicine Research and Practice, 2022,19(1):72-75. DOI：

摘要

目的探讨不同严重程度高胆红素血症新生儿血清总胆红素(TBiL)、谷草转氨酶(AST)、血尿素氮(BUN)、肌酸激酶同工酶(CKMB)及乳酸脱氢酶(LDH)水平的表达及临床意义

旨在为临床高胆红素血症新生儿的诊治以及预后评估提供参考。方法选择2020年4月-2021年4月在郑州市某医院就诊的65例高胆红素血症新生儿作为观察组

选择同期行实验室指标检测的63例健康新生儿作为对照组。观察组患儿根据血清TBiL水平分为重度(TBiL水平>342μmol/L)8例

中度(257～342μmol/L)21例

轻度(TBiL水平<257μmol/L)36例。所有研究对象均进行实验室检测

指标包括AST、CKMB、LDH、BUN、TBiL。对比2组研究对象血清相关实验室检测指标:观察组、对照组的AST、CKMB、LDH、BUN、TBiL水平。对比治疗前后24 h轻度、中度、重度患儿AST、CKMB、LDH、BUN、TBiL水平。对比不同病情患儿预后情况

即统计治疗过程中的并发症发生率。结果观察组研究对象AST、CKMB、LDH、TBiL水平均高于对照组

差异均有统计学意义(P<0.05)。2组研究对象BUN水平比较

差异无统计学意义(P>0.05)。治疗前

中、轻度患儿AST、CKMB、LDH、TBiL水平均低于重度组

轻度组患儿AST、CKMB、LDH、TBiL水平均低于中度组

差异均有统计学意义(P<0.05)。治疗后

3组患儿AST、CKMB、LDH、TBiL水平均低于治疗前

差异均有统计学意义(P<0.05)。中、轻度组患儿AST、CKMB、LDH、TBiL水平均低于重度组

轻度组患儿AST、CKMB、LDH、TBiL水平均低于中度组

差异均有统计学意义(P<0.05)。中、轻度组患儿并发症发生率低于重度组

差异有统计学意义(P<0.05)。轻、中度组患儿并发症发生率比较

差异无统计学意义(P>0.05)。结论 AST、CK-MB、LDH、TBiL联合检测可用于评判高胆红素血症新生儿的病情严重程度

并可指导临床治疗

改善预后质量

值得临床推广。

Abstract

Objective To investigate the expression and clinical significance of serum total bilirubin（TBiL）

aspartate aminotransferase（AST）

blood urea nitrogen（BUN）

creatine kinase myocardial band（CKMB） and lactate dehydrogenase（LDH） levels in neonates with different severity of hyperbilirubinemia

with the aim of providing reference for the diagnosis and treatment as well as prognostic assessment of neonates with hyperbilirubinemia in clinical practice.Methods Sixty-five neonates with hyperbilirubinemia attending a hospital in Zhengzhou from April 2020 to April 2021 were selected as the observation group

and 63 healthy neonates with laboratory indexes tested at the same period were selected as the control group.The children in the observation group were divided into 8 cases with severe（TBiL level >342 μmol/L）

21 cases with moderate（257～342 μmol/L）

and 36 cases with mild（TBiL level <257 μmol/L） hyperbilirubinemia according to the severity of the disease.All study subjects underwent laboratory tests

and the indexes included AST

CKMB

LDH

BUN

and TBiL.Serum-related laboratory test indexes were compared between the 2 groups:AST

CKMB

LDH

BUN

and TBiL levels were recorded in the observation and control groups.The levels of AST

CKMB

LDH

BUN and TBiL inchildren with mild

moderate and severe disease were compared before and after 24 h of treatment.The prognosis of children with different conditions was compared

the incidence of complications during the treatment was counted.Results The levels of AST

CKMB

LDH

and TBiL inthe observation group were lower than those in the control group

and the differences were statistically significant（P<0.05）.The differences were not statistically significant（P>0.05） when comparing the BUN levels in the 2 groups.Before treatment

the levels of AST

CKMB

LDH

and TBiL were lower in the moderate and mild groups than in the severe group

and the higher of AST

CKMB

LDH

and TBiL were lower in the mild group than in the moderate group

and the differences were all statistically significant（P<0.05）.After treatment

the levels of AST

CKMB

LDH and TBiL ofchildren in the three groups were lower than those before treatment

and the differences were all statistically significant（P<0.05）.The levels of AST

CKMB

LDH and TBiL ofchildren in the moderate and mild groups were lower than those in the severe group

and the levels of AST

CKMB

LDH and TBiL ofchildren in the mild group were lower than those in the moderate group

and the differences were all statistically significant（P<0.05）.The complication rates of children in the moderate and mild groups were lower than those in the severe group

and the differences were statistically significant（P <0.05）.There was no statistically significant difference between the complication rates of children in the mild and moderate groups（P >0.05）.Conclusion The combined test of AST

CK-MB

LDH and TBiL iseffective in the clinical management of neonates with hyperbilirubinemia

which can effectively identify the severity of the disease

guide clinical treatment and improve the quality of prognosis

and is worthy of clinical promotion.

关键词

高胆红素血症新生儿预后质量诊治效果病情程度

Keywords

HyperbilirubinemiaNeonatePrognosis qualityDiagnosis and treatment effectDegree of disease

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