Objective To investigate the burnout of health care workers during the pandemic of COVID-19 in order to understand their work status and provide a basis for reducing their physical and mental stress and enhancing their work effectiveness. Methods From January to February 2020

370 clinical health care workers from 29 tertiary care general hospitals in Guangdong Province were selected as survey subjects using a convenience sampling method. The MBI-GS burnout questionnaire was applied to the respondents

and the survey data were statistically analyzed. Results The respondents scored 2.0（1.0

2.6） in the personal emotion dimension

1.0（0.3

1.8） in the depersonalization dimension

and 1.2（0.7

2.8） in the personal fulfillment dimension. The differences in the total scores of the MBI-GS burnout questionnaire were statistically significant（P<0.05） among the respondents of different departments

occupational categories

ages and titles. Emergency department respondents scored 2.0（1.4

2.7） in the personal mood dimension; 1.0（0.5

2.0） in the depersonalization dimension

and 1.4（0.8

2.8） in the personal fulfillment dimension. The differences in the total scores of the MBI-GS burnout questionnaire were statistically significant（P <0.05） among emergency department respondents of different ages and titles. In addition

94.05% of the survey respondents were willing to treat/care for patients with COVID-19

and 96.49% were willing to actively educate patients and their families about protection related to COVID-19. Conclusion Some front-line healthcare workers suffer from burnout and their sense of personal accomplishment needs to be improved. Hospitals should pay attention to the health needs of healthcare workers

reasonably deploy human resources

reduce the workload of special departments

and better enhance the confidence and ability of healthcare workers to resist COVID-19.