Objective To investigate the effects of serum N-terminal pro-brain natriuretic peptide（NT-pro BNP） and galactose lectin-3（Galectin-3） levels on the prognosis of patients with acute ischemic stroke（AIS）.Methods Seventy-six patients with AIS who were treated in a hospital in Zhengzhou from February 2018 to April 2019 were selected for the study and divided into 2 subgroups（mild and severe groups） according to the degree of disease

and 76 physically healthy individuals were taken as the control group during the same period.Serum NT-pro BNP and Galectin-3 levels were compared between the 3 study groups.Patients were divided into good prog-nosis group and poor prognosis group according to their modified Rankin scores（m RS）.Serum NT-pro BNP and Galectin-3 levels were compared between the 2 groups

and their correlation with patient prognosis was analyzed.Results The NT-pro BNP and Galectin-3 levels in the severe group were significantly higher than those in the mild group and the control group

and those in the mild group were significantly higher than those in the control group

and the differences were statistically significant（P<0.05）.The NT-pro BNP and Galectin-3 levels were significantly lower in patients in the good prognosis group than in the poor prognosis group

and the differences were all statistically significant（P <0.05）.The correlation analysis revealed that NT-pro BNP and Galectin-3 levels in patients with AIS were positively correlated with m RS scores（r=0.892

0.987;P<0.05）.Conclusion The more severe the disease and the worse the prognosis

the higher the levels of NT-pro BNP and Galectin-3 in AIS patients

and the combined testing of these two indicators can provide a reference for clinical diagnosis and treatment and prognosis assessment of AIS.