反复呼吸道感染患儿血清25-羟维生素D<sub>3</sub>及免疫球蛋白表达水平分析

陈美洁; 杨俊梅; 杨建丽; 刘倩倩

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反复呼吸道感染患儿血清25-羟维生素D₃及免疫球蛋白表达水平分析

临床医学 | 更新时间：2022-11-04

- 反复呼吸道感染患儿血清25-羟维生素D₃及免疫球蛋白表达水平分析
- Analysis of serum 25-hydroxyvitamin D₃ and immunoglobulin expression levels in children with recurrent respiratory tract infections
- 保健医学研究与实践 2021年18卷第4期页码：62-64
- 作者机构：
  
  郑州大学附属儿童医院/河南省儿童医院/郑州儿童医院/郑州市儿童感染与免疫重点实验室
- 作者简介：
- 基金信息：
  
  河南省医学科技攻关计划(2018020619)
- DOI：
  中图分类号： R725.6
- 纸质出版日期：2021，
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陈美洁, 杨俊梅, 杨建丽, 等. 反复呼吸道感染患儿血清25-羟维生素D₃及免疫球蛋白表达水平分析[J]. 保健医学研究与实践, 2021,18(4):62-64.

Chen Meijie, Yang Junmei, Yang Jianli, et al. Analysis of serum 25-hydroxyvitamin D₃ and immunoglobulin expression levels in children with recurrent respiratory tract infections[J]. Health Medicine Research and Practice, 2021,18(4):62-64.
陈美洁, 杨俊梅, 杨建丽, 等. 反复呼吸道感染患儿血清25-羟维生素D₃及免疫球蛋白表达水平分析[J]. 保健医学研究与实践, 2021,18(4):62-64. DOI：

Chen Meijie, Yang Junmei, Yang Jianli, et al. Analysis of serum 25-hydroxyvitamin D₃ and immunoglobulin expression levels in children with recurrent respiratory tract infections[J]. Health Medicine Research and Practice, 2021,18(4):62-64. DOI：

摘要

目的探讨反复呼吸道感染（RRI）患儿血清25-羟维生素D

[25-（OH）D

]及免疫球蛋表达水平。方法选取2018年1月—2019年12月河南省某医院收治的73例RRI患儿作为观察组

选取同期于医院体检的70例健康儿童作为对照组。采集2组研究对象空腹静脉血

检测血清25-（OH）D

及免疫球蛋白水平

采血后观察组给予补充维生素D

治疗。比较2组研究对象免疫球蛋白A（Ig A）、免疫球蛋白G（Ig G）、免疫球蛋白M（Ig M）、25-（OH）D

水平及25-（OH）D

缺乏率

同时比较观察组患儿治疗前后25-（OH）D

及Ig A、Ig G、Ig M水平。结果观察组血清25-（OH）D

缺乏率高于对照组

正常率低于对照组

差异有统计学意义（P

0.05）;2组血清25-（OH）D

不足率比较差异无统计学意义（P

0.05）。观察组血清25-（OH）D

、Ig A、Ig G水平低于对照组

差异有统计学意义（P

0.05）;2组血清Ig M水平比较差异无统计学意义（P

0.05）。观察组治疗后血清25-（OH）D

、Ig A、Ig G水平高于治疗前

差异有统计学意义（P

0.05）;观察组治疗前后血清Ig M水平比较

差异无统计学意义（P

0.05）。结论 RRI患儿血清25-（OH）D

及免疫球蛋白水平呈低表达

对维生素D

缺乏的患儿补充维生素D

能够调节25-（OH）D

和免疫球蛋白水平。

Abstract

Objective To investigate the serum 25-hydroxyvitamin D

[25-（OH）D

] and immunoglobulin expression levels in children with recurrent respiratory infections（RRI）.Methods Seventy-three cases of children with RRI admitted to a hospital in Henan Province from January 2018 to December 2019 were selected as the observation group

and 70 healthy children who were physically examined at the hospital during the same period were selected as the control group.Fasting venous blood was collected from the 2 groups

serum 25-（OH）D

and immunoglobulin levels were detected

and the observation group was given vitamin D

supplementation after blood collection.The levels of immunoglobulin A（IgA）

immunoglobulin G（IgG）

immunoglobulin M（Ig M）

25-（OH）D

level

and 25-（OH）D

deficiency were com-pared between the two groups

and the levels of 25-（OH）D

and IgA

IgG and IgM in the children in the observation group were also compared before and after treatment.Results The serum 25-（OH）D

deficiency rate in the observation group was higher than that in the control group

and the normal rate was lower than that in the control group

and the difference was statistically significant（P

0.05）;the difference between the serum 25-（OH）D

deficiency rate in the 2 groups was not statistically significant（P

0.05）.Serum 25-（OH）D

Ig A and Ig G levels in the observation group were lower than those in the control group

and the difference was statistically significant（P

0.05）;the difference between serum Ig M levels in the 2 groups was not statistically significant（P

0.05）.In the observation group

serum 25-（OH）D

IgA and IgG levels were higher than those before treatment

and the difference was statistically significant（P

0.05）;the difference between serum IgM levels before and after treatment in the observation group was not statistically significant（P

0.05）.Conclusion Serum 25-（OH）D

and immunoglobulin levels in children with RRI showed low expression

and vitamin D

supplementation in children with vitamin D

deficiency could regulate 25-（OH）D

and immunoglobulin levels.

关键词

反复呼吸道感染儿童血清25-羟维生素D3维生素D免疫功能

Keywords

Recurrent respiratory infectionchildrenSerum 25-hydroxyvitamin D3Vitamin DImmune function

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反复呼吸道感染患儿血清25-羟维生素D3及免疫球蛋白表达水平分析

Analysis of serum 25-hydroxyvitamin D3 and immunoglobulin expression levels in children with recurrent respiratory tract infections

DOI：

摘要

Abstract

关键词

Keywords

references

反复呼吸道感染患儿血清25-羟维生素D₃及免疫球蛋白表达水平分析

Analysis of serum 25-hydroxyvitamin D₃ and immunoglobulin expression levels in children with recurrent respiratory tract infections