Objective To investigate the clinical application of personalized three-dimensional titanium mesh in reconstruction of cranial-orbital defects. Methods This study involved 16 patients with cranial-orbital defects treated at the Affiliated Stomatology Hospital of Southwest Medical University between January 2013 and June2019. The patients all received cranial-orbital defect reconstruction with personalized three-dimensional titanium mesh. Preoperative computed tomography scan was conducted for the preparation of personalized titanium mesh with computer aided design

mirror imaging technology

and rapid prototyping technology

which was implanted to repair the cranio-orbital bone defect. Results The personalized titanium mesh matched the bone defect and was used to reconstruct the shape of craniofacial bone in shorter operation time. During an average follow-up of 3 years

there were no complications such as epileptic seizures and titanium mesh exposure

with normal vision and visual fields and high aesthetic satisfaction. Conclusion Cranial-orbital defect reconstruction with personalized three-dimensional titanium mesh has optimal surgical procedure

improved facial esthetics

less postoperative complications

and shorter operation time. This technology allows accurate and personalized cranial-orbital reconstruction and should be recommended for clinical use.