封闭抗体阴性复发性流产患者应用常规保胎联合免疫球蛋白被动免疫治疗的疗效观察

林晓岚; 林清兰; 陈丽华; 黄丽娟

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封闭抗体阴性复发性流产患者应用常规保胎联合免疫球蛋白被动免疫治疗的疗效观察

临床医学研究 | 更新时间：2023-04-14

- 封闭抗体阴性复发性流产患者应用常规保胎联合免疫球蛋白被动免疫治疗的疗效观察
- Clinical efficacy of conventional tocolytic therapy combined with passive immunoglobulin immunotherapy in blocking antibody-negative recurrent spontaneous abortion patients
- 西南医科大学学报 2021年44卷第2期页码：154-158
- 作者机构：
  
  南方医科大学附属小榄医院妇产科
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R714.21
- 纸质出版日期：2021，
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[1]林晓岚,林清兰,陈丽华,黄丽娟.封闭抗体阴性复发性流产患者应用常规保胎联合免疫球蛋白被动免疫治疗的疗效观察[J].西南医科大学学报,2021,44(02):154-158.

LIN Xiaolan, LIN Qinglan, CHEN Lihua, et al. Clinical efficacy of conventional tocolytic therapy combined with passive immunoglobulin immunotherapy in blocking antibody-negative recurrent spontaneous abortion patients[J]. Journal of Southwest Medical University, 2021,44(2):154-158.
[1]林晓岚,林清兰,陈丽华,黄丽娟.封闭抗体阴性复发性流产患者应用常规保胎联合免疫球蛋白被动免疫治疗的疗效观察[J].西南医科大学学报,2021,44(02):154-158. DOI：

LIN Xiaolan, LIN Qinglan, CHEN Lihua, et al. Clinical efficacy of conventional tocolytic therapy combined with passive immunoglobulin immunotherapy in blocking antibody-negative recurrent spontaneous abortion patients[J]. Journal of Southwest Medical University, 2021,44(2):154-158. DOI：

摘要

目的:观察封闭抗体阴性的复发性流产患者应用常规保胎治疗联合免疫球蛋白被动免疫治疗的临床疗效。方法:选取2018年1月至2019年4月来本院就诊的（recurrent spontaneous sbortion

RSA）早孕保胎患者共108例

分为对照组和观察组。对照组采用常规保胎治疗

观察组在对照组的基础上添加丙种免疫球蛋白被动免疫治疗。治疗期间监测两组患者孕6、8和11周的血清β-HCG及孕酮水平

定期进行B超检查

监测胚胎发育情况

比较两组患者治疗前后CD19

、自然杀伤（NK）细胞、CD3

、CD4

及CD8

细胞水平变化

比较两组患者妊娠成功率及不良反应发生率。结果:在妊娠的第6、8和11周

观察组患者血清β-HCG及孕酮水平均显著高于对照组患者（P

0.05）。对两组患者治疗前后CD19

、NK细胞、CD3

、CD4

及CD8

水平之差进行检测

对照组患者治疗前后CD19

、NK细胞、CD3

、CD4

及CD8

水平变化均明显低于观察组患者（P

0.05）。对照组患者妊娠成功率为44.44%

观察组患者妊娠成功率达81.48%

观察组妊娠成功率高于对照组

差异有统计学意义（P

0.05）。对照组患者发生不良反应共13例

发生率为24.07%

观察组患者发生不良反应共14例

发生率为25.93%

与对照组相比

差异无统计学差异（P

0.05）。结论:常规保胎治疗联合丙种免疫球蛋白被动免疫治疗能够提高封闭抗体阴性的RAS患者妊娠成功率

改善其相关免疫指标

可作为临床治疗的有效手段。

Abstract

Objective:To evaluate the clinical efficacy of conventional tocolytic therapy combined with passive immunoglobulin immunotherapy in blocking antibody（BA）-negative recurrent spontaneous abortion（RSA） patients.Methods:A total of 108 RSA patients in early pregnancy who were admitted to our hospital from January 2018 to April 2019 were randomly divided into control group and observation group.The control group was treated with conventional tocolytic therapy

and the observation group was given conventional tocolytic therapy plus passive immunoglobulin immunotherapy.Post-treatment serum β-HCG and progesterone levels were monitored at weeks 6

and11 of pregnancy in the two groups.Ultrasound was performed regularly to monitor embryo development.Changes in the percentages of CD19

CD3

CD4

and CD8

cells after treatment were examined and compared between the two groups.Pregnancy success rate and adverse reaction rate were compared between the two groups.Results:At weeks 6

and 11 of pregnancy

serum β-HCG and progesterone levels were significantly higher in the observation group than in the control group（P

0.05）.The changes in the percentages of CD 19

CD3

CD4

and CD8

cells after treatment were significantly lower in the control group than in the observation group（P

0.05）（Table 2）.The pregnancy success rate was significantly higher in the observation group than in the control group（81.48% vs44.44%

0.05）.However

there was no significant difference in the adverse reaction rate between the control group（13 cases

24.07%） and the observation group（14 cases

25.93%）（P

0.05）.Conclusion:Conventional tocolytic therapy combined with passive immunoglobulin immunotherapy can improve the pregnancy success rate and immune parameters of BA-negative RSA patients

and may therefore be an effective clinical treatment for RAS.

关键词

复发性流产封闭抗体阴性丙种免疫球蛋白

Keywords

Recurrent spontaneous abortionBlocking antibody-negativeImmunoglobulin

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