After acute ischemic stroke

secondary neuroinflammation can not only promote the damage of brain tissues and lead to cell death

but also promote the rehabilitation of patients. Proinflammatory signals from immune mediators rapidly activate the resident microglia and affect a variety of inflammatory cells（neutrophils

mononuclear macrophages

different subtypes of T cells

and other inflammatory cells） to infiltrate into the ischemic area

causing an overreaction of immune inflammation and aggravating the brain tissue damage. However

there are also some related studies which demonstrate that some immune cells have a protective effect on brain tissues. This article reviews the changes in imune cells after ischemic stroke

and further discusses the immune-related targeted therapy

which is of great significance to the prognosis of patients.