Natural compounds isolated from plants exhibit significant anti-leukemia activity

and related mechanisms include inhibiting proliferation

inducing apoptosis and differentiation

promoting cell cycle arrest

and reversing drug resistance of leukemia cells. They can act as therapeutic or adjuvant agents to improve the efficacy of conventional chemotherapy and radiotherapy. This article reviews the research on the anti-leukemia activity of natural compounds and the signaling pathways involved in the anti-leukemia effect of different natural compounds based on their chemical structures

so as to provide a theoretical basis for the clinical application of natural compounds and the development of new drugs.