Objective To explore the current situation of adverse drug use among college students in order to provide basis for guiding rational drug use among college students. Methods A total of 1 158 college students from a non-medical university were selected by stratified random sampling. The questionnaire included the basic information of the subjects

the source of medicine

unhealthy medication behavior

etc. SPSS 21.0 software was used for statistical analysis. Results The main sources of medicine were school hospital（50.2%）

social pharmacy（33.0%） and social hospital/clinic（15.2%）. 45.7% of the subjects often did not read the main text of the drug instructions before medication

and 19.6% of the subjects often missed the medication without cause during the medication period. 22.1% of the subjects had used drugs beyond the expiration date

and the proportion of subjects with different genders

places of origin

monthly living expenses and medical insurance coverage who had used drugs beyond the expiration date was statistically significant（P <0.05）.32.1% of the subjects had used drinks to deliver drugs

and the proportion of subjects with different genders

places of origin and monthly living expenses had statistically significant differences（P <0.05）.19.5% of the subjects did not follow the drug instructions or medical advice

and the proportion of subjects with different genders

places of origin and medical insurance coverage who did not follow the drug instructions or medical advice was statistically significant（P <0.05）.Conclusion According to the current situation of adverse drug use among college students

targeted health education measures should be taken to guide the rational drug use among college students.