Objective To investigate the effects of reduced glutathione（GSH） in treating Cr

6+

-induced skin lesions in rats. Methods Thirty SD rats were selected as experimental animals and randomly divided into two groups

i.e.

the experimental and control groups

with 15 rats in each group. The rats were clipped on the back and neck and then shaved with a dermatome to expose the skin

and 0.5 m LCr O

3

（0.1 mol/L） solution was injected intra-dermally. After 1 week

the surface of the skin was keratinized

and the scab was removed with a scalpel to form a chromic sore. The experimental group was given self-made GSH gel 6 times a day for 1 week

while the control group used blank self-made gel at the same time. The morphology and changes of the chrome ulcers as well as the growth of new granulation tissues were observed daily. Results Five cases were healed in the experimental group and another 3 cases were found to be effective

with a total healing rate of 53.3%; 2 cases were healed in the control group and 1 case was found to be effective

with a total healing rate of 20.0%. The ANOVA analysis of repeated measurements showed that there were statistically significant effects of intervention

time effect and interaction between groups and time in the two groups（P

<

0.05）. The wound diameter of rats in the experimental group showed a decreasing trend compared with the control group

indicating that the treatment effect of the experimental group was better than the control group. Conclusion GSH has therapeutic effect on skin and muscle tissue injury caused by Cr

6+

and can accelerate the healing of chrome ulcers and the production of new tissue.