Objective To explore the application of information management in the occupational exposure of medical staff and its effects. Methods One hundred and fifty-one members of the medical staff of a hospital in Chongqing who underwent occupational exposure from January 2016 to December 2019 were selected as the research subjects. Medical workers who underwent occupational exposure from January 2016 to December 2017 were taken as the control group（n= 66）

while those who underwent occupational exposure from January 2018 to December 2019

i.e. after the implementation of informatization management were taken as the observation group（n=85）. The two groups were compared in respect to occupational exposure reporting time

follow-up inspection delay time

time for infection control personnel to verify occupational exposure and feedback to the department

execution rate of basic occupational exposure information registration（including the description of exposure methods

exposure sources

post-exposure treatment

occupational exposure assessment and treatment

post-exposure preventive treatment plan change feedback） and occupational exposure financial reimbursement time. Results After the implementation of information management

the occupational exposure reporting time of medical staff was（0.64±0.05）h

shorter than that of the control group

which was（2.50±0.04）h; the delay time of follow-up inspection was（1.19±0.08）d

shorter than（3.22±0.13）d for the control group; the time for infection control personnel to verify occupational exposure and feedback to the department was（13.06±2.07）min

shorter than（30.11±3.09） min for the control group; the occupational exposure financial reimbursement time was（1.08±0.04）d

shorter than that of the control group

which was（3.02±0.54）d. All differences were statistically significant（P<0.05）. After the implementation of information management

the excecution rate of exposure method description

exposure source

post-exposure treatment

occupational exposure assessment and treatment

and post-exposure preventive treatment plan change feedback was higher than that of the control group

and the difference was statistically significant（P<0.05）. Conclusion Informatization management can effectively reduce the risk of occupational exposure for medical staff

improve the efficiency of reporting the occupational exposure information

and realize precise information management.