Objective To explore the clinical effect of prednisone acetate combined with Bupi Wenshen Lishui Decoction in the treatment of primary nephrotic syndrome（PNS）.Methods A total of 100 PNS patients treated in a nephrology department of a hospital in Liaoning Province from November 2018 to May 2019 were selected as the research subjects.Patients were divided into a control group and a study group using a random number table method.50 cases in each group.Patients in the control group were given oral prednisone acetate.Patients in the study group were treated with the homemade Bupi Wenshen Lishui Decoction based on the treatment of the control group.Patients in both groups were treated for 30 days.Compare the TCM syndrome main points

the 24-hour urine protein quantification

the high-sensitivity C-reactive protein（hs-CRP）

the serum cortisol（CORT）

and the adrenocorticotropic hormone（ACTH）levels of the two groups of patients before and after treatment

patient treatment effect.Results After treatment

the scores of edema

chills

cold limbs

waist and knee cold pain

fatigue

lack of appetite

and stool in the two groups of patients were lower than those before treatment.The score of the study group was lower than that of the control group

and the differences were statistically significant（P<0.05）.After treatment

the quantification of 24 hurine protein and hs-CRP levels in the study group were（0.96±0.18）g and（4.21±1.07）mg/L

which were lower than those in the control group（1.15±2.25）g and（15.05±4.02）mg/L

and the 24-hour urine protein and hs-CRP levels of the two groups were lower than before treatment

and the differences were statistically significant（P<0.05）.The CORT and ACTH levels in the study group were（189.87±52.55）ng/mL and（23.23±7.40）pg/mL

which were higher than those in the control group（97.34±23.66）ng/mL and（15.88±4.38）pg/mL.The differences were statistically significant（P<0.05）.The total effective rate of patients in the study group was 92.0%

which was higher than 70.0%in the control group

and the difference was statistically significant（P<0.05）.Conclusion Prednisone acetate combined with Bupi Wenshen Lishui Decoction for PNS can effectively improve the treatment effect

suppress inflammatory response

improve glomerular filtration rate

improve edema

chills

cold limbs

cold pain in waist and knees

fatigue symptoms such as dyspepsia

anorexia

stool dysentery

etc.have significant clinical effects and are worthy of popularization and application.