Objective To explore the efficacy and safety of EC sequential T regimen（epirubicin+cyclophosphamide

sequential taxotere）in patients with radical mastectomy.Methods Eighty-eight patients who underwent chemotherapy after radical mastectomy in a hospital in Liaoning Province were selected for the study.The patients were divided into study group（n=46）and control group（n=42）according to the postoperative chemotherapy regimens.Patients in control group received TEC regimen（taxotere+ epirubicin+ cyclophosphamide）after surgery

and patients in study group received EC sequential T regimen chemotherapy after surgery.The short-term clinical efficacy

occurrence of toxic and side effects during chemotherapy and quality of life after 1 month at the end of chemotherapy were compared between the two groups.Results The RR and DSR were73.91%（34/46）and 91.30%（42/46）in study group

which were higher than those in control group with52.38%（22/42）and 73.81%（31/42）（P<0.05）.During chemotherapy

the incidence rates of leukopenia and thrombocytopenia were 50.00%（23/46）and 45.65%（21/46）in study group

which were lower than those in control group with 66.67%（28/42）and 66.67%（28/42）（P<0.05）.After 1 month at the end of chemotherapy

the scores of survival status

social/family status

emotional status and functional status and total score of Functional Assessment of Cancer Therapy-General（FACT-G）in study group were higher than those in control group（P<0.05）.Conclusion EC sequential T regimen chemotherapy has better short-term efficacy of patients after radical mastectomy than TEC regimen

and it can reduce the incidence rates of toxic and side effects of leukopenia and thrombocytopenia

and can help improve the quality of life of patients.