Objective To investigate the significance of Notch1 and PTEN on bronchial asthma in children.Methods A total of 41 children with bronchial asthma（the study group）and 40 healthy children（the control group）in a hospital in Henan from January 2015 to January 2018 were selected as study objects.Indexes of pulmonary function[forced expiratory volume in one second（FEV1）

FEV1/forced vital capacity（FVC）

middle forced expiratory flow（FEF25%-75%）

forced expiratory flow at 50% of FVC（FEF50%）

forced expiratory flow at75% of FVC（FEF75%）and fractional exhaled nitric oxide（FeNO）]

interleukin-6（IL-6）and eosinophils（Eos）were detected;expression levels of Notch1 and PTEN mRNA were detected by qRT-PCR;all data were statistically analyzed.Results FEV1

FEV1/FVC

FEF25%-75%

FEF50%and FEF75%in the study group were（1.38±0.65）L

（60.35±10.42）%

（3.15±1.23）L/s

（1.76±0.79）L/s and（0.78±0.54）L/s

respectively.All were lower than those in the control group

which were（2.47±0.53）L

（79.46±13.26）%

（4.09±1.57）L/s

（2.57±1.03）L/s and（1.25±0.38）L/s

respectively（all P

<

0.05）.FeNO in the study group was（17.35±11.53）ppb

which was higher than that of（10.46±4.25）ppb in the control group（P

<

0.05）.Eos and IL-6 in the study group were（0.36±0.13）×109/L and（0.73±0.17）ng/mL

rspectively.Both were higher than those in the control group

which were（0.16±0.11）×109/L and（0.38±0.14）ng/mL

respectively（both P

<

0.05）.Level of Notch1 mRNA in the study group was 1.52±0.13

which was significantly higher than that of 0.87±0.09 in the control group（P

<

0.05）.Level of PTEN mRNA in the study group was 0.38±0.08

which was significantly lower than that of 1.17±0.19 in the control group（P

<

0.05）.The corresponding analysis results showed that expression level of Notch1 mRNA was negatively related with FEV

1

FEV

1

/FVC

FEF25%-75%

FEF50%and FEF75%（all P

<

0.05）

and was positively related with FeNO

IL-6 and Eos（all P

<

0.05）.Expression level of PTEN mRNA was positively related with FEV

1

FEV

1

/FVC

FEF25%-75%

FEF50% and FEF75%（all P

<

0.05）

and was negatively related with FeNO

IL-6 and Eos（all P

<

0.05）.Expression of Notch1 mRNA was negatively related with expression of PTEN mRNA（P

<

0.05）.Conclusion Upregulation of Notch1 level in children with asthma can suppress the expression of PTEN and promote the expression of inflammation factors like IL-6

so as to induce the development and progression of asthma.