Objective To assess the clinical efficacy of ureteroscopic pneumatic ballistic lithotripsy plus transurethral resection of prostate（TURP）for the treatment of benign prostatic hyperplasia（BPH）complicated with bladder stones.Methods A total of 106 patients with both BPH and bladder stones who were treated at a Henan hospital between October 2015 and November 2018 were included in this study.Based on a random number table

patients were randomized to receive suprapubic cystolithotomy plus TURP（control group

n=53）or ureteroscopic pneumatic ballistic lithotripsy plus TURP（trial group

n=53）

respectively.The time to stone clearance

intraoperative blood loss volume

duration of bladder irrigation

duration of catheter indwelling

length of hospital stay

occurrence of complications

pre-and post-operative International Prostate Symptom Score（IPSS）

and levels of inflammatory factors were compared between the two groups.Results The time to stone clearance was similar between the two groups（P>0.05）.The intraoperative blood loss volume in the trial group was significantly smaller than that in the control group（89.37±16.28 mL versus 132.94±20.03 mL

P<0.05）.The duration of bladder irrigation

duration of catheter indwelling

and length of hospital stay in the trial group were significantly shorter compared with the control group（27.73±3.24 hversus 56.48±5.37 h

3.76±0.26 dversus8.89±2.88 d

6.21±2.26 dversus 11.44±4.27 d

all P<0.05）.The baseline IPSS scores were comparable between the two groups（P>0.05）;at 2 months after surgery

the IPSS scores were reduced from baseline in both groups

with a significantly greater reduction in the trial group（P<0.05）.The baseline serum levels of IL-10

IL-6

CRP and TNF-αwere similar between the two groups（all P>0.05）;at 7 days after surgery

all of these levels were reduced from baseline in both groups

with significantly greater reductions in the trial group（all P<0.05）.The incidence of complications was similar between the two groups（P>0.05）.Conclusion For patients with BPH and bladder stones

ureteroscopic pneumatic ballistic lithotripsy plus TURP is reliably safe and effective

which may not only relieve prostate symptoms and enhance quality of life

but also improve clinical biomarkers and reduce complication risk.