Objective To compare the efficacy of tolterodine versus solifenacin in relieving lower urinary tract symptoms（LUTS）caused by ureteral stents（double J tube）

so as to provide evidence for clinical management.Methods Ninety-six patients with indwelling double J tube after ureteroscopic lithotripsy who were treated at a Chengdu hospital between January 2015 and December 2016 were included in this study.Based on a random number table

these patients were divided into the control group

tolterodine group

and solifenacin group

32 patients in each group.All Patients received oral levofolxacin（0.5 g

once daily）

those in the tolterodine group also received tolterodine tartrate（4 mg

once daily）

and those in the solifenacin group were treated with solifenacin succinate（5 mg

once daily）in addition to levofolxacin.At 4 weeks

the Ureteral Stent Symptom Questionnaire（USSQ）and WHO Quality of Life-Brief Scale（WHOQOL-BREF）were used to assess the LUTS and QOL

respectively.Meanwhile

adverse events were monitored during the study.Results The urinary frequency

urgency

incontinence

lumbago

abdominal pain

and urethralgia scores in USSQ were 3.15±1.82

3.52±1.37

0.68±0.25

2.38±1.58

2.63±1.47

and 1.45±1.36 in the control group

respectively;2.08±1.89

1.26±1.31

0.16±0.19

0.87±1.43

0.59±1.38

and 0.96±1.38 in the tolterodine group

respectively;and 2.14±1.87

1.35±1.25

0.18±0.21

0.98±1.68

0.67±1.27

and 0.94±1.31 in the solifenacin group

respectively.All of these scores were significantly lower in both the tolterodine group and the solifenacin group as compared with the control group（all P<0.05）;but these scores were comparable between the tolterodine group and the solifenacin group（P>0.05）.The scores of the physical and psychological domains in WHOQOL-BREF were14.91±2.65 and 14.85±2.45 in the control group

respectively;16.47±2.58 and 16.78±2.98 in the tolterodine group

respectively;and 16.24±2.47 and 16.98±2.34 in the solifenacin group

respectively.Both scores were significantly higher in the tolterodine group and the solifenacin group as compared with the control group（both P<0.05）

but similar between the tolterodine group and the solifenacin group（P>0.05）.Conclusion Compared with levofolxacin alone

tolterodine or solifenacin combined with levofolxacin seems to be more effective in relieving LUTS caused by double J tube

such as urinary frequency

urgency

incontinence

lumbago

abdominal pain

and urethralgia

which may substantially improve the quality of life of these patients.When added to levofolxacin

tolterodine and solifenacin have comparable efficacy

both of which may be selected according to the specific clinical conditions.