Objective To investigate the influencing factors of perihematomal edema expansion in patients with hypertensive cerebral hemorrhage

which may provide theoretical evidence for the development of clinical interventions.Methods A total of 143 patients with hypertensive cerebral hemorrhage who were treated at a Zunyi hospital during the period from January 2015 to December 2017 were included in this study.These patients were divided into the edema expansion group（n=68）and the no edema expansion group（n=75）.The gender composition

age

duration of disease

use of medications（with or without the use of amlodipine

mannitol

and ACEI）

and blood pressure variability were compared between the two groups

and then the influencing factors of perihematomal edema expansion in patients with hypertensive cerebral hemorrhage were assessed.Results The proportions of patients with disease duration≥10 dand those with significant blood pressure variability were higher in the edema expansion group as compared with the no edema expansion group

but the use of amlodipine was less frequent in the edema expansion group（P<0.05）.The Logistic multiple regression analysis indicated that

disease duration≥10 dand significant blood pressure variability were risk factors for perihematomal edema expansion in patients with hypertensive cerebral hemorrhage

while use of amlodipine was a protective factor for this（P<0.05）.Conclusion In patients with hypertensive cerebral hemorrhage

perihematomal edema expansion may be influenced by several factors.Early intervention is important for these patients

so as to shorten the duration of cerebral hemorrhage;meanwhile blood pressure management should be strengthened

especially the use of amlodipine

which may reduce blood pressure variability and thereby prevent perihematomal edema expansion and improve patient prognosis.