Objective To assess the effect of platelet-rich fibrin（PRF）membrane on gingival healing

bone mass preservation and newly regenerated bone when used for ridge preservation with guided bone regeneration（GBR）.Methods A total of 60 patients who underwent GBR ridge preservation after tooth extraction at a Hubei hospital between January 2015 and January 2017 were included in this study.Based on a random number table

patients were divided into the trial group（n=30）and the control group（n=30）.All patients received minimally invasive extraction and ridge preservation with GBR.In the trial group

PRF membrane was used to cover the surface of bone substitute material Bio-Oss

while in the control group

Heal-All collagen membrane was used.The time to wound healing

wound healing rate

height and width of alveolar bone（both before extraction and 3 months after extraction）

as well as the percentage of newly regenerated bone were compared between the two groups.Results As compared with the control group

the time to wound healing was significantly shorter in the trial group（P<0.05）;the wound healing rates at 1 week and 2 weeks after tooth extraction were significantly higher in the trial group（P<0.05）.Before extraction

the height and width of alveolar bone were similar between the two groups（P>0.05）;at 3 months after extraction

the height and width of alveolar bone were decreased in both groups

but those in the trial group were significantly larger compared with the control group（P<0.05）.The newly regenerated gingival histology in the trial group was similar to the condition after two years of natural healing

while the newly regenerated bone histology in the control group was similar to the condition after two years of natural healing.The percentage of newly regenerated bone was significantly higher in the trial group than that in the control group（P<0.05）.Conclusion When used for GBR ridge preservation

PRF is effective in promoting the wound healing of gingival tissues

inhibiting alveolar bone absorption

preventing further bone mass loss

and facilitating the formation of newly regenerated bone

which may provide a sound condition for subsequent dental implant and thus deserves widespread clinical application.